期刊简介
《医学争鸣》是由第四军医大学主办，国内外公开征稿和发行的综合性医学学术期刊，是原《第四军医大学学报》的延续。期刊以反映发明与创新、否定与假说、探索与发现等前沿医学思想，传播医学领域新观点、新方法和新成就，服务医学科学研究和我国卫生事业发展为宗旨。主要报道医学学术方面的各种看法和观点，注重理性的交锋、实证的研讨和冷静的争论。
首页>医学争鸣杂志
- 杂志名称：医学争鸣杂志
- 主管单位：第四军医大学
- 主办单位：第四军医大学
- 国际刊号：1674-8913
- 国内刊号：61-1481/R
- 出版周期：双月刊
期刊荣誉：2010年获全军医学期刊“创新奖”期刊收录：北大核心期刊(中国人文社会科学核心期刊), CA 化学文摘(美), 维普收录(中), 国家图书馆馆藏, 知网收录(中), 上海图书馆馆藏, JST 日本科学技术振兴机构数据库(日)
Low-dose radiation on spinal cord might be a new therapy for intractable chronic cancer and non-cancer pain
ZHU Gui-Qin；HE Xue-Ming；LIU Su；DONG Yan-Bin；LIU Yue-Peng
关键词：Radiation, chronic pain, spinal cord, dendritic spine
摘要：Intractable chronic pain is a great challenge in clinic.Central sensitization based on the positive changes of dendritic spines is the main mechanism of intractable chronic pain.And low-dose radiation has been proved to regulate the changes of dendritic spines negatively.Hence,we make a hypothesis that low-dose radiation could relieve cancer and noncancer pain through negatively regulating the shape and reducing the number and density of dendritic spines in the spinal cord.This method is supposed to be a new therapy for intractable chronic pain by expanding indication to non-cancer pain,translocating radiation site from where the tumor exists to special segments of spinal cord and keeping radiation dose at a low level.This therapy would be reliable for relieving non-cancer pain and supply more choices for relieving cancer pain.
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